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In PKA catalytic subunit , R165 and D166 in the [HY]-[RY]-D-[LI]-K-P-[ED]-N motif (aka RD motif) and the D184, F185, and G186 residues (aka DFG motif) (Fig 4A) are critical for its kinase activity (Hanks & Hunter, 1995)

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Abbreviations LC : Lung Cancer SCLC : Small Cell Lung Cancer NSCLC : Non-Small Cell Lung Cancer IARC : International Agency for Research on Cancer WHO : World Health Organization MDI : Metered Dose Inhaler DPI : Dry Powder Inhaler AC : Adenocarcinoma SQCC : Squamous Cell Carcinoma RTK : Receptor Tyrosine Kinase EGFR : Epidermal Growth Factor Receptor ALK : Anaplastic Lymphoma Kinase HER2 : Human Epidermal Growth Factor Receptor 2 MET : Mesenchymal Epithelial Transition RET : Rearranged during Transfection MAPK : Mitogen-Activated Protein Kinase PI3K/AKT : Phosphatidylinositol-3 Kinase/Protein Kinase B TKI : Tyrosine Kinase Inhibitor FGFR1 : Fibroblast Growth Factor Receptor 1 DDR2 : Discoindin Domain Receptor 2 RAS/RAF : Rat Sarcoma Virus/Rapidly Accelerated Fibrosarcoma KRAS : Kirsten Rat Sarcoma Grb2 : Growth Factor Receptor-Bound Protein 2 SOS : Son of Sevenless MEK : Mitogen-Activated Protein Kinase Kinase BRAF : V-raf murine sarcoma viral oncogene homolog B1 mTOR : Mammalian Target of the Rapamycin PTEN : Phosphatase and Tensin JAK/STAT : Janus Kinase/Signal Transducer and Activator of Transcription CDK : Cyclin Dependent Kinase SMARCA4 : SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin A4 ARID1A : AT-rich interaction domain 1A KEAP1 : Kelch-like ECH-associated protein 1 NFE2L2 : Nuclear Factor Erythroid-Derived 2-Like 2 SOX2 : SRY-box transcription factor 2 Notch : Neurogenic Locus Notch Homolog Protein NKX2-1 : NK2 Homeobox-1 pMDIs : Pressurized Metered Dose Inhalers COPD : Chronic Obstructive Pulmonary Disease SMIs : Soft Mist Inhalers TME : Tumor Microenvironment SLNs : Solid Lipid Nanoparticles ECM : Extracellular Matrix MDR : Multidrug Resistance IL-6 : Interleukin-6 TNF- : Tumour Necrosis Factor- FPF : Fine Particle Fraction MMAD : Mass Median Aerodynamic Diameter t : 1/2 Half-Life AUC : Area Under Curve PLGA : Poly(lactic-co-glycolic acid) PEG : Polyethylene Glycol NLCs : Nanostructured Lipid Carriers VEGFR : Vascular Endothelial Growth Factor Receptors EGFR : Epidermal Growth Factor Receptor CFC : Chlorofluorocarbon MTX : Methotrexate PAMAM : Poly(amidoamine) VMN : Vibrating Mesh Nebulizer ChP : Chinese Pharmacopeia EP : European Pharmacopeia USP : United States Pharmacopeia GSD : Geometric Standard Deviation BSA : Bovine Serum Albumin PEI : Polyethyleneimine References Chaitanya Thandra K, Barsouk A, Saginala K, Sukumar Aluru J, Barsouk A